2019-6-1 · Di(2-ethylhexyl) phthalate (DEHP) increases proliferation of epithelial breast cancer cells through progesterone receptor dysregulation
2017-12-5 · Di(2-ethylhexyl)phthalate (DEHP) a widely used plasticizer mainly serves as an additive to render polyvinyl chloride (PVC) soft and flexible. PVC plastics have become ubiquitous in our modern society. Yet the leaching of DEHP from PVC-based consumables ultimately results in the deposition in certain tissues via inadvertent applications.
Bis(2-ethylhexyl) phthalate is a phthalate ester that is the bis(2-ethylhexyl) ester of benzene-1 2-dicarboxylic acid has a role as an apoptosis inhibitor an androstane receptor agonist and a plasticiser. It is a phthalate ester and a diester.
2019-12-12 · Packed school meals for children 3–10 years old were studied to evaluate the levels of di(2-ethylhexyl)phthalate (DEHP) and di-n-butylphthalate (DBP) and the influence of the packaging process on meal contamination and their contribution to daily intake was estimated. The packaging consisted of polyethylene-coated aluminum (PE/Al) dishes thermally welded by a polyethyleneterephthalate
Di(2-ethylhexyl) phthalate (DEHP) is widely used in polyvinylchloride-based materials and remains intact in the environment. Lungs are one route of entry of DEHP into the body however there is limited information on the effects and mechanism of action of DEHP on non-small cell lung cancer (NSCLC).
2021-7-22 · DEHP (di(2-ethylhexyl)phthalate) may increase the risk of cancer and may harm the male reproductive system. Also exposure to DEHP during pregnancy may affect the development of the child. DIDP (di-isodecyl phthalate) during pregnancy may affect the development of the child. DINP (diisononyl phthalate) may increase the risk of cancer.
2016-2-6 · Di(2-ethylhexyl)phthalate (DEHP) is an estrogenic chemical that is widely used in polyvinyl products. We aimed to determine the mechanisms behind the effects of DEHP on ERα-negative breast cancer cells MDA--231 invasion and matrix metalloproteinases-2/-9 (MMP-2/-9) up-regulation in this study. Transwell assay indicated that DEHP exposure (>50 μg/ml) significantly enhanced the invasion
2021-7-18 · Di(2-ethylhexyl) Phthalate CAS No. 117-81-7 Reasonably anticipated to be a human carcinogen First listed in the Third Annual Report on Carcinogens (1983) Also known as DEHP diethylhexyl phthalate or dioctyl phthalate C O O C H2C CH H2 C O O C H2 CH H2C C H2 H2 C CH3 C H2 CH3 CH3 C H2 H2 C CH3 H2 C Carcinogenicity Di(2-ethylhexyl) phthalate
2017-12-5 · Di(2-ethylhexyl)phthalate (DEHP) a widely used plasticizer mainly serves as an additive to render polyvinyl chloride (PVC) soft and flexible. PVC plastics have become ubiquitous in our modern society. Yet the leaching of DEHP from PVC-based consumables ultimately results in the deposition in certain tissues via inadvertent applications.
2018-2-22 · Di-2-ethylhexyl phthalate (DEHP) is extensively used as a plasticizer in many products especially medical devices furniture materials cosmetics and personal care products. DEHP is noncovalently bound to plastics and therefore it will leach out of these products after repeated use heating and/or cleaning of the products. Due to the overuse of DEHP in many products it enters and
1. Cancer Lett. 1984 Aug24(1) 49-55. Di(2-ethylhexyl)phthalate but not phenobarbital promotes N-nitrosodiethylamine-initiated hepatocellular proliferative lesions after short-term exposure in male B6C3F1 mice. Ward JM Ohshima M Lynch P Riggs C.
2011-12-20 · Mechanistic considerations for human relevance of cancer hazard of di(2-ethylhexyl) phthalate. Rusyn I 1 Corton JC 2. Author information. Affiliations. 1 author. 1. Department of Environmental Sciences and Engineering University of North Carolina Chapel Hill
Di (2-ethylhexyl) phthalate (DEHP) which is widely used in polyvinyl chloride materials can be easily accumulated into human body. Lung cancer cells can be directly exposed to DEHP via inhalation however the effects and related mechanisms of DEHP on the progression of non small cell lung cancer (NSCLC) were not illustrated.
2020-9-3 · Wang Y. et al. Up regulation of IL-6 is involved in di (2-ethylhexyl) phthalate (DEHP) induced migration and invasion of non small cell lung cancer (NSCLC) cells. Biomed. Pharmacother. 89 1037
2021-4-28 · 7/1/2020 Di(2-ethylhexyl)phthalate (DEHP) DEHP is on the Proposition 65 list because it can cause cancer and birth defects or other reproductive harm. Exposure to DEHP may increase the risk of cancer and may also harm the male reproductive system.
Di(2-ethylhexyl) phthalate (DEHP) is widely used in polyvinylchloride-based materials and remains intact in the environment. Lungs are one route of entry of DEHP into the body however there is limited information on the effects and mechanism of action of DEHP on non-small cell lung cancer (NSCLC).
2018-2-22 · Di-2-ethylhexyl phthalate (DEHP) is extensively used as a plasticizer in many products especially medical devices furniture materials cosmetics and personal care products. DEHP is noncovalently bound to plastics and therefore it will leach out of these products after repeated use heating and/or cleaning of the products.
2012-4-1 · Di(2-ethylhexyl) phthalate (DEHP) is a peroxisome proliferator agent that is widely used as a plasticizer to soften polyvinylchloride plastics and non-polymers. there is little epidemiological evidence on possible associations between exposure to DEHP and liver cancer in humans. Data are available to suggest that liver is not the only
2016-10-7 · The plasticizer di (2-ethylhexyl) phthalate (DEHP) is ubiquitous in the environment and considered as carcinogen however the carcinogenic risk of human exposure to DEHP in the air via inhalation is lacking.
Di (2-ethylhexyl) phthalate (DEHP) is widely used in polyvinylchloride-based materials and remains intact in the environment. Lungs are one route of entry of DEHP into the body however there is limited information on the effects and mechanism of action of DEHP on non-small cell lung cancer (NSCLC).
2018-6-28 · Di(2-ethylhexyl) phthalate . 151. IARC MONOGRAPHS101 phthalates were produced in the USA in 1999 (ATSDR 2002). Information available in 2010 indicated that DEHP was produced by 23 companies in the USA 19 companies in Mexico nine compa
The current United States Environmental Protection Agency (EPA) classification of di(2-ethylhexyl)phthalate (DEHP) as a B2 "probable human" carcinogen is based on outdated information. New toxicology data and a considerable amount of new mechanistic evidence were used to reconsider the cancer classi
2019-1-1 · Di(2-ethylhexyl) phthalate (DEHP) is widely used in polyvinylchloride-based materials and remains intact in the environment. Lungs are one route of entry of DEHP into the body however there is limited information on the effects and mechanism of action of DEHP on non-small cell lung cancer
Di (2-ethylhexyl) phthalate (DEHP) which is widely used in polyvinyl chloride materials can be easily accumulated into human body. Lung cancer cells can be directly exposed to DEHP via inhalation however the effects and related mechanisms of DEHP on the progression of non small cell lung cancer (NSCLC) were not illustrated.
2018-6-28 · Di(2-ethylhexyl) phthalate . 151. IARC MONOGRAPHS101 phthalates were produced in the USA in 1999 (ATSDR 2002). Information available in 2010 indicated that DEHP was produced by 23 companies in the USA 19 companies in Mexico nine compa
Environmental Health Perspectives Vol. 65 pp. 279-291 1986 Tumor-Initiating and Promoting Activities of Di(2-ethylhexyl) Phthalate in Vivo and in Vitro by J. M. Ward B. A. Diwan M. Ohshima H. Hu H. M. Schuller t and J. M. Rice The carcinogenic effects of di(2-ethylhexyl) phthalate (DEHP) including its potential as an initiator and as a promoter of carcinogenesis were studied in
Di(2-ethylhexyl) phthalate (DEHP) is widely used in polyvinylchloride-based materials and remains intact in the environment. Lungs are one route of entry of DEHP into the body however there is limited information on the effects and mechanism of action of DEHP on non-small cell lung cancer (NSCLC).
1999-6-1 · The current United States Environmental Protection Agency (EPA) classification of di(2-ethylhexyl)phthalate (DEHP) as a B2 "probable human" carcinogen is based on outdated information. New toxicology data and a considerable amount of new mechanistic evidence were used to reconsider the cancer classification of DEHP under EPA s proposed new cancer risk assessment guidelines.
The current United States Environmental Protection Agency (EPA) classification of di(2-ethylhexyl)phthalate (DEHP) as a B2 "probable human" carcinogen is based on outdated information. New toxicology data and a considerable amount of new mechanistic evidence were used to reconsider the cancer classification of DEHP under EPA s proposed new
2021-6-25 · Bis(2-ethylhexyl phthalate is also called di(2-ethylhexyl)phthalate or DEHP . (1) DEHP is a colorless liquid with almost no odor. (1) The chemical formula for DEHP is C 24 H 38 O 4 and the molecular weight is 390.57 g/mol. (1) The vapor pressure for DEHP is 6.2 10-8 mm Hg at 25 °C and it has a log octanol/water partition coefficient (log K ow
Di (2-ethylhexyl) phthalate (DEHP) which is widely used in polyvinyl chloride materials can be easily accumulated into human body. Lung cancer cells can be directly exposed to DEHP via inhalation however the effects and related mechanisms of DEHP on the progression of non small cell lung cancer (NSCLC) were not illustrated.
2021-1-7 · Di-(2-ethylhexyl) phthalate (DEHP) is a male reproductive toxicant. This research is aimed at investigating the effect of pubertal DEHP exposure on testicular endoplasmic reticulum (ER) stress and germ cell apoptosis. Five-week-old male mice were orally administered with DEHP (0 0.5 50 or 500 mg/kg/day) for 35 days. Testis weight and sperm count were reduced in mice exposed to 500
Di(2-ethylhexyl) phthalate (DEHP) is widely used in polyvinylchloride-based materials and remains intact in the environment. Lungs are one route of entry of DEHP into the body however there is limited information on the effects and mechanism of action of DEHP on non-small cell lung cancer (NSCLC). Here we addressed this by examining the effect of DEHP on the proliferation of A549 human lung
2013-7-18 · To evaluation of the contribution of DEHP (di-(2-ethylhexyl) phthalate) to the pathophysiology of endometriosis ECC-1 (human endometrial cancer) cell lines were subjected to DEHP for 48 h with 50 μM DEHP and total RNA was extracted. Quantified spectro-photometrically and RNA quality was verified via agarose-gel electrophoresis. Gene expression changes were analyzed using oligonucleotide
2018-2-22 · Di-2-ethylhexyl phthalate (DEHP) is extensively used as a plasticizer in many products especially medical devices furniture materials cosmetics and personal care products. DEHP is noncovalently bound to plastics and therefore it will leach out of these products after repeated use heating and/or cleaning of the products. Due to the overuse of DEHP in many products it enters and
2012-4-1 · Di (2-ethylhexyl) phthalate (DEHP) is a peroxisome proliferator agent that is widely used as a plasticizer to soften polyvinylchloride plastics and non-polymers.
Bis(2-ethylhexyl) phthalate is a phthalate ester that is the bis(2-ethylhexyl) ester of benzene-1 2-dicarboxylic acid has a role as an apoptosis inhibitor an androstane receptor agonist and a plasticiser. It is a phthalate ester and a diester.
1. Cancer Lett. 1984 Aug24(1) 49-55. Di(2-ethylhexyl)phthalate but not phenobarbital promotes N-nitrosodiethylamine-initiated hepatocellular proliferative lesions after short-term exposure in male B6C3F1 mice. Ward JM Ohshima M Lynch P Riggs C.
The current United States Environmental Protection Agency (EPA) classification of di(2-ethylhexyl)phthalate (DEHP) as a B2 "probable human" carcinogen is based on outdated information. New toxicology data and a considerable amount of new mechanistic evidence were used to reconsider the cancer classification of DEHP under EPA s proposed new
2016-2-6 · Di(2-ethylhexyl)phthalate (DEHP) is an estrogenic chemical that is widely used in polyvinyl products. We aimed to determine the mechanisms behind the effects of DEHP on ERα-negative breast cancer cells MDA--231 invasion and matrix metalloproteinases-2/-9 (MMP-2/-9) up-regulation in this study. Transwell assay indicated that DEHP exposure (>50 μg/ml) significantly enhanced the invasion
Bis(2-ethylhexyl) phthalate is a phthalate ester that is the bis(2-ethylhexyl) ester of benzene-1 2-dicarboxylic acid has a role as an apoptosis inhibitor an androstane receptor agonist and a plasticiser. It is a phthalate ester and a diester.